Multidrug resistance in cancer: role of ATP–dependent transporters
Copyright policy )Multidrug resistance in cancer: role of ATP–dependent transporters
Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become simultaneously resistant to different drugs--a trait known as multidrug resistance--remains a significant impediment to successful chemotherapy. Three decades of multidrug-resistance research have identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy.
- National Cancer Institute United States
- National Institutes of Health United States
- National Institute of Health Pakistan
- Center for Cancer Research United States
ATP-Binding Cassette, Sub-Family C Proteins, Leukemia, Antineoplastic Agents, Breast Neoplasms, Drug Resistance, Multiple, Permeability, Neoplasm Proteins, Structure-Activity Relationship, Adenosine Triphosphate, Drug Resistance, Neoplasm, Organ Specificity, Drug Design, Multigene Family, Neoplasms, Humans, ATP-Binding Cassette Transporters, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1, Biomarkers, Forecasting
ATP-Binding Cassette, Sub-Family C Proteins, Leukemia, Antineoplastic Agents, Breast Neoplasms, Drug Resistance, Multiple, Permeability, Neoplasm Proteins, Structure-Activity Relationship, Adenosine Triphosphate, Drug Resistance, Neoplasm, Organ Specificity, Drug Design, Multigene Family, Neoplasms, Humans, ATP-Binding Cassette Transporters, Female, ATP Binding Cassette Transporter, Subfamily B, Member 1, Biomarkers, Forecasting
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