Polycomb silencers control cell fate, development and cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2006 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Cancer, volume 6, pages 846-856 (issn: 1474-175X, eissn: 1474-1768,

Copyright policy )

Authors: Anke, Sparmann; Maarten, van Lohuizen;

doi: 10.1038/nrc1991

pmid: 17060944

Polycomb silencers control cell fate, development and cancer

- Summary
- Subjects
- Metrics

Abstract

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.

Related Organizations

Netherlands Heart Institute
Netherlands
Antoni van Leeuwenhoek Hospital
Netherlands

Keywords

Repressor Proteins, Neoplasms, Animals, Humans, Polycomb-Group Proteins, Apoptosis, Gene Silencing

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	1K
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 0.1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 0.1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 0.1%