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Nature Genetics
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Nature Genetics
Article . 1992 . Peer-reviewed
License: Springer TDM
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Nature Genetics
Article . 1993
Data sources: Europe PubMed Central
Nature Genetics
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Molecular evolution of the human interleukin–8 receptor gene cluster

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1992 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 2, pages 31-36 (issn: 1061-4036, eissn: 1546-1718, Copyright policy )
Authors: Philip M. Murphy; Tayfun Ozcelik; Athena Milatovitch; Sunil K. Ahuja; Uta Francke;

doi: 10.1038/ng0992-31

pmid: 1303245

Molecular evolution of the human interleukin–8 receptor gene cluster

Abstract

Interleukin-8 (IL-8) is the prototype for a family of at least eight neutrophil chemoattractants whose genes map to human chromosome 4q13-q21. Two human IL-8 receptors, IL8RA and IL8RB, are known from cDNA cloning; IL8RA is a promiscuous receptor for at least two other related ligands, GRO alpha and NAP-2. We now report cloning of the genes for IL8RA, IL8RB and a recently inactivated pseudogene of receptor A (IL8RAP). These form a cluster of only three genes in the superfamily of G protein-coupled receptors (GPCRs) and map to 2q34-q35. The coevolutionary diversity displayed by the IL-8 ligand-receptor complex--ligand promiscuity for IL-8, receptor promiscuity for IL8RA, gene duplication for both ligands and receptors and gene extinction in the case of IL8RAP--is unprecedented for the GPCR superfamily.

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Keywords

Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Chromosome Mapping, DNA, Biological Evolution, Polymerase Chain Reaction, Receptors, Interleukin-8A, Multigene Family, Humans, Amino Acid Sequence, Chromosomes, Human, Pair 4, Receptors, Immunologic, Pseudogenes

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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