Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Naturearrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Nature
Article
License: CC 0
Data sources: UnpayWall
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Nature
Article . 1986 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
Nature
Article . 1986
Data sources: Europe PubMed Central
https://dx.doi.org/10.1038/319...
Article
Data sources: Microsoft Academic Graph
https://dx.doi.org/10.1038/319...
Article
Data sources: Microsoft Academic Graph
 View all 2 versions
Claim

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1986 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 319, pages 743-748 (issn: 0028-0836, eissn: 1476-4687, Copyright policy )
Authors: D, Martin-Zanca; S H, Hughes; M, Barbacid;

doi: 10.1038/319743a0

pmid: 2869410

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

Abstract

A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.

Keywords

Base Sequence, DNA, Oncogenes, Tropomyosin, Protein-Tyrosine Kinases, Cell Transformation, Neoplastic, Humans, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Poly A

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 843
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 0.1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
    OpenAIRE UsageCounts
    Usage byUsageCounts
    visibility views 65
    download downloads 38
  • 65
    views
    38
    downloads
    Powered byOpenAIRE UsageCounts
Powered by OpenAIRE graph
Found an issue? Give us feedback
visibility
download
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
OpenAIRE UsageCountsDownloads provided by UsageCounts
843
Top 1%
Top 0.1%
Top 0.1%
65
38
hybrid