AbstractAseismic afterslip has been proposed to drive aftershock sequences. Both afterslip moment and aftershock number broadly increase with mainshock size, but can vary beyond this scaling. We examine whether relative afterslip moment (afterslip moment/mainshock moment) correlates with several key aftershock sequence characteristics, including aftershock number and cumulative moment (both absolute and relative to mainshock size), seismicity rate change, b‐value, and Omori decay exponent. We select Mw ≥ 4.5 aftershocks for 41 tectonically varied mainshocks with available afterslip models. Against expectation, relative afterslip moment does not correlate with tested aftershock characteristics or background seismicity rate. Furthermore, adding afterslip moment to mainshock moment does not improve predictions of aftershock number. Our findings place useful empirical constraints on the link between afterslip and potentially damaging Mw ≥ 4.5 aftershocks and raise questions regarding the role afterslip plays in aftershock generation.