Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel “Rule-Breaker” Iodidoplatinum(II) Complex
Copyright policy )Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel “Rule-Breaker” Iodidoplatinum(II) Complex
Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
- National Research Council Italy
- University of Pisa Italy
- University of La Laguna Spain
- Ecole Polytechnique Fédérale de Lausane Switzerland
- Autonomous University of Madrid Spain
Pyridine, Compound, Platination, Dna, Metallodrug-Protein Interactions, Insights, Iodidoplatinum complex, Platinum Antitumor Drugs, Esi, DNA and protein interaction; Iodidoplatinum complex, cytotoxicity, Heart Cytochrome-C, Mass-Spectrometry, DNA and protein interaction
Pyridine, Compound, Platination, Dna, Metallodrug-Protein Interactions, Insights, Iodidoplatinum complex, Platinum Antitumor Drugs, Esi, DNA and protein interaction; Iodidoplatinum complex, cytotoxicity, Heart Cytochrome-C, Mass-Spectrometry, DNA and protein interaction
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