Development of a Modified System to Provide Improved Diastereocontrol in the Linear-Selective Cu-Catalyzed Reductive Coupling of Ketones and Allenamides

descriptionPublicationkeyboard_double_arrow_right Article 19 Oct 2021 English Publisher:American Chemical Society (ACS)Journal:The Journal of Organic Chemistry, volume 87, pages 2,142-2,153 (issn: 0022-3263, eissn: 1520-6904,

Copyright policy )

Authors: Dang Ho; Samantha Gargaro; Raphael Klake; Joshua Sieber;

doi: 10.1021/acs.joc.1c02062 , 10.26434/chemrxiv-2021-g2xbm

pmid: 34807603

Development of a Modified System to Provide Improved Diastereocontrol in the Linear-Selective Cu-Catalyzed Reductive Coupling of Ketones and Allenamides

- Summary
- Subjects
- Metrics

Abstract

Chiral g-lactones are prevalent organic architectures found in a large array of natural products. In this work, we disclose the development of a modified catalytic system utilizing a commercially available Cu-phosphite catalyst for the diastereoselective reductive coupling of chiral allenamides and ketones to afford chiral -lactone precursors in 80:20 to 99:1 dr.

Related Organizations

Virginia Commonwealth University
United States

Keywords

Stereoisomerism, Ketones, Catalysis

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	13
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%