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UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2002 English Publisher:Elsevier BVJournal:Molecular Genetics and Metabolism, volume 75, pages 369-373 (issn: 1096-7192,

Authors: Yang, Xiaolin; Pratley, Richard E.; Tokraks, Stephen; Antonio Tataranni, P.; Permana, Paska A.;

doi: 10.1016/s1096-7192(02)00008-2

pmid: 12051969

UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates

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Abstract

Uncoupling protein 5 (UCP5) or brain mitochondrial carrier protein-1 (BMCP1) enhances mitochondrial proton leak in vitro and its hepatic and brain expression profiles are modulated by diet and cold exposure in mice. Alternative splicing generates three isoforms: a long form (UCP5L), a short form (UCP5S), and a short form with a 31 amino acid insert (UCP5SI). We investigated the relationship between skeletal muscle UCP5 expression and in vivo energy metabolism in 36 non-diabetic Pima Indians. We determined the expression levels of total UCP5 (UCP5T), and the isoforms UCP5L, UCP5S, and UCP5SI (66.8, 32.5, and 0.8% of UCP5T, respectively). None correlated with body weight or percent body fat. The transcript level of UCP5SI, but not the others, was positively correlated with resting metabolic rate (r=0.38, P=0.02, adjusted for age, sex, fat mass, and fat-free mass) and lipid oxidation rate (adjusted for age, sex, and percent body fat) during a euglycemic clamp with infusion of insulin at a physiologic concentration (r=0.42, P=0.01).

Related Organizations

National Institute of Health
Pakistan
National Institute of Diabetes and Digestive and Kidney Diseases
United States
National Institutes of Health
United States

Keywords

Adult, Male, Adolescent, Transcription, Genetic, Membrane Transport Proteins, Nerve Tissue Proteins, Lipid Metabolism, Asian People, Glucose Clamp Technique, Indians, North American, Humans, Insulin, Protein Isoforms, Female, Mitochondrial Uncoupling Proteins, Basal Metabolism, RNA, Messenger, Carrier Proteins, Muscle, Skeletal, Oxidation-Reduction

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