Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2023 English Publisher:Elsevier BVJournal:Phytochemistry, volume 207, page 113,565 (issn: 0031-9422,

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Authors: Li, Jin-Sheng; Liu, Yi-Nan; Li, Jing-Ya; Lei, Chun; Hou, Ai-Jun;

doi: 10.1016/j.phytochem.2022.113565

pmid: 36549384

Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase

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Abstract

Five undescribed enantiomeric pairs of acylphloroglucinol-monoterpene meroterpenoids ((+)-/(-)-eucateretins A-E) resolved by chiral-phase HPLC were obtained from the leaves of Eucalyptus tereticornis Smith, along with nine known analogues. Their structures were elucidated by spectroscopic methods and ECD calculations. This is the first report of meroterpenoid enantiomers from this plant. Some of the isolates, (-)-eucateretin A, (+)-/(-)-eucateretins E, 7'α-eucalrobusone X, eucalrobusone X, and robustadial B, exhibited inhibitory effects on ATP citrate lyase, and 7'α-eucalrobusone X significantly suppressed the hepatocyte lipogenesis.

Related Organizations

Shanghai Jiao Tong University
China (People's Republic of)
Fudan University
China (People's Republic of)
Shanghai Institute of Materia Medica
China (People's Republic of)
University of Chinese Academy of Sciences
China (People's Republic of)
Chinese Academy of Sciences
China (People's Republic of)

Keywords

Plant Leaves, Eucalyptus, Molecular Structure, Monoterpenes, ATP Citrate (pro-S)-Lyase, Biodiversity, Acyltransferases, Taxonomy

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