Anti-tumor alkaloids from Peganum harmala

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2022 English Publisher:Elsevier BVJournal:Phytochemistry, volume 197, page 113,107 (issn: 0031-9422,

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Authors: Zhang, Qin; Zan, Yan-Hui; Yang, Han-Gao; Yang, Meng-Yue; Liu, Fang-Shen; Li, Sheng-Ge; Peng, Xiao-Hui; +4 Authors

doi: 10.1016/j.phytochem.2022.113107

pmid: 35121215

Anti-tumor alkaloids from Peganum harmala

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Abstract

Six alkaloids peharmalines F-K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC50 value of 3.05 μM. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC50 values of 16.45 μM and 17.27 μM, respectively.

Related Organizations

Shenyang Pharmaceutical University
China (People's Republic of)

Keywords

Alkaloids, A549 Cells, Plant Extracts, Humans, Peganum, Biodiversity, Hep G2 Cells, Antineoplastic Agents, Phytogenic, Taxonomy

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