Long-chain fatty acid acylated derivatives of isoflavone glycosides from the rhizomes of Iris domestica

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2022 English Publisher:Elsevier BVJournal:Phytochemistry, volume 193, page 112,977 (issn: 0031-9422,

Copyright policy )

Authors: Li, Jiayuan; Ni, Gang; Liu, Yanfei; Wang, Renzhong; Yu, Dequan;

doi: 10.1016/j.phytochem.2021.112977

pmid: 34715401

Long-chain fatty acid acylated derivatives of isoflavone glycosides from the rhizomes of Iris domestica

- Summary
- Subjects
- Metrics

Abstract

Six undescribed long-chain fatty acid esters of isoflavone glycosides were obtained from the rhizomes of Iris domestica (L.). Their structures were elucidated by comprehensive spectroscopic data, alkaline hydrolysis, and acid hydrolysis. This is the first report of the long-chain (C14-C18) fatty acid derivatives of isoflavone glycosides from natural products. Belamcandnoate B and D exhibited moderate cytotoxic activities against HCT-116, HepG2, and BGC823 cell lines with IC50 values of 1.69-6.86 μM. Belamcandnoate B and E exhibited 72.27 and 58.98% inhibitory activities, respectively, against Fe2+/cysteine-induced liver microsomal lipid peroxidation at a concentration of 10 μM.

Related Organizations

PEKING UNION MEDICAL COLLEGE
China (People's Republic of)
Chinese Academy of Medical Sciences & Peking Union Medical College
China (People's Republic of)

Keywords

Iris Plant, Fatty Acids, Biodiversity, Glycosides, Isoflavones, Rhizome, Taxonomy

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	6
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%