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Phytochemistry
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Phytochemistry
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Cytotoxic triterpenoids from Chisocheton pentandrus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2021 English Publisher:Elsevier BVJournal:Phytochemistry, volume 187, page 112,759 (issn: 0031-9422, Copyright policy )
Authors: Salam, Supriatno; Harneti, Desi; Maharani, Rani; Nurlelasari; Safari, Agus; Hidayat, Ace Tatang; Lesmana, Ronny; +4 Authors

doi: 10.1016/j.phytochem.2021.112759

pmid: 33839518

Cytotoxic triterpenoids from Chisocheton pentandrus

Abstract

Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of the stem bark of Chisocheton pentandrus (Blanco) Merr. These comprised ten undescribed dammarane-type triterpenoids and one undescribed apotirucallane-type triterpenoid. Additionally, two dammarane-type triterpenoids, four apotirucallane-type triterpenoids and two tirucallane-type triterpenoids were also isolated. The chemical structures of pentandrucine A-K, were fully elucidated using 1D and 2D-NMR, and high resolution MS. All of the compounds were evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol proved to be the most active with an IC50 of 16.84 μM comparing favourably with Cisplatin (13.2 μM).

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Keywords

Molecular Structure, Humans, Antineoplastic Agents, Biodiversity, Meliaceae, Antineoplastic Agents, Phytogenic, Triterpenes, Taxonomy

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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