Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2021 English Publisher:Elsevier BVJournal:Phytochemistry, volume 187, page 112,705 (issn: 0031-9422,

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Authors: Khamidulla Kamoldinov; Jun Li; Komila Eshbakova; Shamansur Sagdullaev; Gaoya Xu; Yubo Zhou; Jia Li; +1 Authors

doi: 10.1016/j.phytochem.2021.112705

pmid: 33957541

Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity

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Abstract

Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A-I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC50 values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively.

Related Organizations

Chinese Academy of Sciences
China (People's Republic of)
Academy of Sciences Republic of Uzbekistan
Uzbekistan
State Key Laboratory of Drug Research
China (People's Republic of)
Xinjiang Technical Institute of Physics & Chemistry
China (People's Republic of)
Shanghai Institute of Materia Medica
China (People's Republic of)

Keywords

Molecular Structure, Coumarins, Biodiversity, Plant Roots, Sesquiterpenes, Taxonomy, Ferula

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