Tirucallane triterpenoids from the mastic (Pistacia lentiscus) and their anti-inflammatory and cytotoxic activities

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2021 English Publisher:Elsevier BVJournal:Phytochemistry, volume 182, page 112,596 (issn: 0031-9422,

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Authors: Liu, Wei; Gao, Jie; Li, Miaomiao; Aisa, Haji Akber; Yuan, Tao;

doi: 10.1016/j.phytochem.2020.112596

pmid: 33321444

Tirucallane triterpenoids from the mastic (Pistacia lentiscus) and their anti-inflammatory and cytotoxic activities

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Abstract

Phytochemical investigation of mastic, a resin produced by Pistacia lentiscus, led to the isolation and identification of 16 tirucallane triterpenoids, 13 (1-13) of which are undescribed. Their structures and absolute configurations were elucidated based on the analysis of spectroscopic data and single-crystal X-ray diffraction. Compounds 12 and 13 are unusual 7(8 → 9)abeo-tirucallane triterpenoids. Anti-inflammatory assays indicated that compounds 7, 8, 14, and 16 exhibited stronger inhibitory NO production activities (IC50 = 7.7-13.4 μM) than that of the positive control dexamethasone (IC50 = 19.5 μM). In addition, compound 1 showed comparable cytotoxic activity against HepG2 cells to that of doxorubicin (IC50 = 4.92 VS 1.34 μM).

Related Organizations

Chinese Academy of Sciences
China (People's Republic of)
University of Chinese Academy of Sciences
China (People's Republic of)
Xinjiang Technical Institute of Physics & Chemistry
China (People's Republic of)
Jiangxi Normal University
China (People's Republic of)

Keywords

Pistacia, Anti-Inflammatory Agents, Biodiversity, Antineoplastic Agents, Phytogenic, Triterpenes, Taxonomy

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