Ent-clerodane and ent-trachylobane diterpenoids from Croton dictyophlebodes

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2020 United Kingdom English Publisher:Elsevier BVJournal:Phytochemistry, volume 179, page 112,487 (issn: 0031-9422,

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Authors: Munissi, Joan J.E.; Isyaka, Sani M.; Mas-Claret, Eduard; Brabner, Molly; Langat, Moses K.; Nyandoro, Stephen S.; Mulholland, Dulcie A.;

doi: 10.1016/j.phytochem.2020.112487

pmid: 32847772

Ent-clerodane and ent-trachylobane diterpenoids from Croton dictyophlebodes

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Abstract

The stem bark and root bark extracts of Croton dictyophlebodes (Euphorbiaceae) yielded seven undescribed ent-clerodanes: 15,16-epoxy-17,12(S)-olide-ent-cleroda-1,3,13(16),14-tetraen-18-oic acid methyl ester (crotodictyo A), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-20-al (crotodictyo B), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-19,20-dioic acid (crotodictyo C), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-20,19-olide (crotodictyo D), 3β,4β:15,16-diepoxy-20,12(R)-olide ent-cleroda-13(16),14-dien-19-oic acid methyl ester (crotodictyo E), 15,16-epoxy-ent-cleroda-3,13(16),14-trien-12-oxo-18-oic acid (crotodictyo F) and 15,16-epoxy-ent-cleroda-1,3,13(16),14-tetraen-12-oxo-18-oic acid (crotodictyo G), in addition to 15,16-epoxy- ent-cleroda-3,13(16),14-trien-12-oxo-18-oic acid methyl ester (crotodictyo H), reported previously as a synthetic derivative, and acetyl aleuritolic acid. The root extract yielded two ent-trachylobanes, ent-trachylobane-18,19-diol, the undescribed ent-trachylobane-2α,19-diol, along with ent-kaur-16-en-19-oic acid and 2-methoxybenzyl benzoate. Compounds were evaluated against the NCI 60 panel of human tumour cell lines at a single dose of 10-5 M, but showed no significant activity.

Country

United Kingdom

Related Organizations

Royal Botanic Gardens
United Kingdom
University of KwaZulu-Natal
South Africa
University of Dar es Salaam
Tanzania (United Republic of)
University of Surrey
United Kingdom

Keywords

Molecular Structure, Croton dictyophlebodes; Euphorbiaceae; Ent-clerodane; Ent-trachylobane; Cytotoxicity screening; Electronic circular dichroism, Cell Line, Tumor, Euphorbiaceae, Humans, Biodiversity, Croton, Diterpenes, Taxonomy, Diterpenes, Clerodane

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