Iridoids and bis-iridoids from Valeriana jatamansi and their cytotoxicity against human glioma stem cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2020 English Publisher:Elsevier BVJournal:Phytochemistry, volume 175, page 112,372 (issn: 0031-9422,

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Authors: Quan, Li-Qiu; Hegazy, Ahmed-Mohamed; Zhang, Zhi-Jun; Zhao, Xu-Dong; Li, Hong-Mei; Li, Rong-Tao;

doi: 10.1016/j.phytochem.2020.112372

pmid: 32305683

Iridoids and bis-iridoids from Valeriana jatamansi and their cytotoxicity against human glioma stem cells

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Abstract

An undescribed iridoid (valeridoid A) and five undescribed bis-iridoids (valeridoids B-F), along with four known ones, were isolated from the roots and rhizomes of Valeriana jatamansi. Their structures were elucidated based on 1D and 2D NMR, as well as HRESIMS spectroscopic data. In addition, 8,9-didehydro-7-hydroxydolichodial and valeridoid F were found to inhibit the growth of three human glioma stem cells (GSC-3#, GSC-12# and GSC-18#).

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Keywords

Molecular Structure, Valerian, Neoplastic Stem Cells, Humans, Iridoids, Biodiversity, Plant Roots, Taxonomy, Nardostachys

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