Siphonagarofurans A-J: Poly-O-acylated β-dihydroagarofuran sesquiterpenoids from the fruits of Siphonodon celastrineus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2020 English Publisher:Elsevier BVJournal:Phytochemistry, volume 174, page 112,345 (issn: 0031-9422,

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Authors: Singha, Suriphon; Yotmanee, Pathumwadee; Yahuafai, Jantana; Siripong, Pongpun; Prabpai, Samran; Sutthivaiyakit, Somyote;

doi: 10.1016/j.phytochem.2020.112345

pmid: 32200067

Siphonagarofurans A-J: Poly-O-acylated β-dihydroagarofuran sesquiterpenoids from the fruits of Siphonodon celastrineus

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Abstract

Ten poly-O-acylated β-dihydroagarofuran sesquiterpenoids, siphonagarofurans A-J, were obtained from the fruits of Siphonodon celastrineus using chromatographic techniques. Their structures were elucidated by extensive use of 2-D NMR spectroscopic methods. The absolute configurations of siphonagarofurans A-J were assigned following analysis of calculated and experimental ECD spectra. The absolute configuration of siphonagarofuran A was also confirmed by X-ray crystallographic analysis. Selected compounds were evaluated for their cytotoxic activity against KB, Vero and Hela cell lines with siphonagarofuran J identified as the most active compound, with IC50 values ranging from 14 to 27 μM.

Related Organizations

Ramkhamhaeng University
Thailand

Keywords

Fruit, Humans, Biodiversity, Celastraceae, Sesquiterpenes, Taxonomy, HeLa Cells

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