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Triterpenoids from the barks of Juglans hopeiensis

Name: Triterpenoids from the barks of Juglans hopeiensis
Keywords: Models, Molecular, Dose-Response Relationship, Drug, Molecular Structure, Cell Survival, Phytochemicals, Juglans, Biodiversity, Hep G2 Cells, Crystallography, X-Ray, Antineoplastic Agents, Phytogenic

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2020 English Publisher:Elsevier BVJournal:Phytochemistry, volume 170, page 112,201 (issn: 0031-9422,

Authors: Peng, Xiaogang; Lin, Yi; Liang, Jingjing; Zhou, Ming; Zhou, Jia; Ruan, Hanli;

doi: 10.1016/j.phytochem.2019.112201

pmid: 31778881

Triterpenoids from the barks of Juglans hopeiensis

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Abstract

Nine undescribed triterpenoids (jughopenoids A-I), including seven nortriterpenoids and two normal triterpenoids, together with fourteen known analogues, were isolated from the barks of Juglans hopeiensis Hu. The structures of the undescribed triterpenoids were established by integrated spectroscopic analysis and single crystal X-ray diffraction. Jughopenoid A represented an unprecedented lupane-type nortriterpenoid with a five-membered lactone ring A. Selected isolates were tested for their cytotoxic effects against human HT-29 colon carcinoma, human HepG2 hepatocellular carcinoma, and human PC-3 prostate cancer cell lines. Their immunosuppressive activities against ConA-induced T cell proliferation and LPS-induced B cell proliferation were also evaluated.

Related Organizations

Wuhan Union Hospital
China (People's Republic of)
Huazhong University of Science and Technology
China (People's Republic of)

Keywords

Models, Molecular, Dose-Response Relationship, Drug, Molecular Structure, Cell Survival, Phytochemicals, Juglans, Biodiversity, Hep G2 Cells, Crystallography, X-Ray, Antineoplastic Agents, Phytogenic, Triterpenes, Structure-Activity Relationship, PC-3 Cells, Plant Bark, Humans, Drug Screening Assays, Antitumor, HT29 Cells, Taxonomy, Cell Proliferation

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