Antimicrobial mechanism of reaction products of Morus notabilis (mulberry) polyphenol oxidases and chlorogenic acid

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2019 English Publisher:Elsevier BVJournal:Phytochemistry, volume 163, pages 1-10 (issn: 0031-9422,

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Authors: Liu, Dan; Meng, Shuai; Xiang, Zhonghuai; He, Ningjia; Yang, Guangwei;

doi: 10.1016/j.phytochem.2019.03.026

pmid: 30974396

Antimicrobial mechanism of reaction products of Morus notabilis (mulberry) polyphenol oxidases and chlorogenic acid

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Abstract

Herein, five polyphenol oxidases (PPOs) obtained from Morus notabilis (Mn) were characterized. Chlorogenic acid was the most readily oxidized substrate by these MnPPOs, and the products derived from the oxidation of chlorogenic acid by MnPPOs were tested for antimicrobial activity. The results showed that products of the five MnPPOs exhibited good inhibitory effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Sclerotinia sclerotiorum, and Botrytis cinerea. Because the products of MnPPO1 exhibited the strongest antimicrobial activity, the antimicrobial mechanism of these products was explored. The results showed that the products of MnPPO1 increased cell membrane permeability and chitinase and β-1,3-glucanase activities.

Related Organizations

Southeast University
China (People's Republic of)

Keywords

Staphylococcus aureus, Antifungal Agents, Biodiversity, Microbial Sensitivity Tests, Moraceae, Anti-Bacterial Agents, Tracheophyta, Magnoliopsida, Ascomycota, Pseudomonas aeruginosa, Escherichia coli, Amino Acid Sequence, Botrytis, Morus, Rosales, Chlorogenic Acid, Plantae, Sequence Alignment, Catechol Oxidase, Taxonomy

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