Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2014 English Publisher:Elsevier BVJournal:Phytochemistry, volume 100, pages 150-155 (issn: 0031-9422,

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Authors: Manase, Mahenina Jaovita; Mitaine-Offer, Anne-Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Delemasure, Stéphanie; Dutartre, Patrick; Lacaille-Dubois, Marie-Aleth;

doi: 10.1016/j.phytochem.2013.12.005

pmid: 24507482

Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst

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Abstract

Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.

Related Organizations

Université Bourgogne Franche-Comté
France
University of Burgundy
France
Kyushu University
Japan

Keywords

Inhibitory Concentration 50, Cell Line, Tumor, Humans, Caryophyllaceae, Biodiversity, Saponins, Antineoplastic Agents, Phytogenic, Triterpenes, Taxonomy

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