Abstract Following the guiding “3R” principle of sustainable development (Reduce, Reuse and Recycle), the potential applicability concerning various components of construction and demolition waste (C&DW) was investigated for radionuclide sorption (Sr, Co, Ni). Collected samples of waste concrete, facade, bricks and asphalt were characterized in respect to mineralogical and surface composition, pH and radioactivity, while their sorption capacities were determined in batch conditions. Selectivity of potential sorbents differed in respect to Co 2+ and Ni 2+ ions, whereas sorption of Sr 2+ was generally low. Concrete and facade have demonstrated both: the highest sorption capacities and the strongest interaction with the investigated cations, as revealed by sequential extraction analysis of loaded sorbents. Taking into account chemical compatibility with mixtures, commonly used for the solidification of radioactive waste, and expressed high affinity for studied cations, waste cement materials and debris are promising matrices for radionuclide immobilization.