Voltage‐dependent anion‐selective channel (VDAC) in the plasma membrane

descriptionPublicationkeyboard_double_arrow_right Article 23 Feb 2010 Italy English Publisher:WileyJournal:FEBS Letters, volume 584, pages 1,793-1,799 (issn: 0014-5793, eissn: 1873-3468,

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Authors: DE PINTO, Vito Nicola; MESSINA, Angela Anna; D. J. LANE; A. LAWEN;

doi: 10.1016/j.febslet.2010.02.049

pmid: 20184885

handle: 20.500.11769/5349

Voltage‐dependent anion‐selective channel (VDAC) in the plasma membrane

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Abstract

Voltage‐dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane‐bound VDAC, and we critically analyze the evidence for VDAC plasma membrane localization obtained from various purification strategies and recently from plasma membrane proteomics studies. We discuss the possible biological function and relevance of VDAC in the plasma membrane and finally discuss a hypothetical model of how VDAC may be targeted to the plasma membrane.

Country

Italy

Related Organizations

Monash University
Australia
University of Catania
Italy

Keywords

Voltage-dependent anion-selective channel, Protein Transport, Cell Membrane, Voltage-dependent anion-selective channel; Mitochondria; Plasma membrane; NADH-oxidoreductase; Dynamic membrane protein redistribution, Animals, Humans, Voltage-Dependent Anion Channels, Models, Biological, Substrate Specificity

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