Abstract We have determined the Wadati–Benioff Zone seismicity and state of stress of the subducting Nazca slab beneath central and southern Peru using data from three recently deployed local seismic networks. Our relocated hypocenters are consistent with a flat slab geometry that is shallowest near the Nazca Ridge, and changes from steep to normal without tearing to the south. These locations also indicate numerous abrupt along-strike changes in seismicity, most notably an absence of seismicity along the projected location of subducting Nazca Ridge. This stands in stark contrast to the very high seismicity observed along the Juan Fernandez ridge beneath central Chile where, a similar flat slab geometry is observed. We interpret this as indicative of an absence of water in the mantle beneath the overthickened crust of the Nazca Ridge. This may provide important new constraints on the conditions required to produce intermediate depth seismicity. Our focal mechanisms and stress tensor inversions indicate dominantly down-dip extension, consistent with slab pull, with minor variations that are likely due to the variable slab geometry and stress from adjacent regions. We observe significantly greater variability in the P-axis orientations and maximum compressive stress directions. The along strike change in the orientation of maximum compressive stress is likely related to slab bending and unbending south of the Nazca Ridge.