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Computer Methods and Programs in Biomedicine
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Non-small cell lung cancer diagnosis aid with histopathological images using Explainable Deep Learning techniques

Authors: Civit Masot, Javier; Bañuls Beaterio, Alejandro; Domínguez Morales, Manuel Jesús; Rivas Pérez, Manuel; Muñoz Saavedra, Luis; Rodríguez Corral, José María;

Non-small cell lung cancer diagnosis aid with histopathological images using Explainable Deep Learning techniques

Abstract

Lung cancer has the highest mortality rate in the world, twice as high as the second highest. On the other hand, pathologists are overworked and this is detrimental to the time spent on each patient, diagnostic turnaround time, and their success rate.In this work, we design, implement, and evaluate a diagnostic aid system for non-small cell lung cancer detection, using Deep Learning techniques.The classifier developed is based on Artificial Intelligence techniques, obtaining an automatic classification result between healthy, adenocarcinoma and squamous cell carcinoma, given an histopathological image from lung tissue. Moreover, a report module based on Explainable Deep Learning techniques is included and gives the pathologist information about the image's areas used to classify the sample and the confidence of belonging to each class.The results show a system accuracy between 97.11 and 99.69%, depending on the number of classes classified, and a value of the area under ROC curve between 99.77 and 99.94%.The classification results obtain a substantial improvement according to previous works. Thanks to the given report, the time spent by the pathologist and the diagnostic turnaround time can be reduced.

Country
Spain
Keywords

Lung Neoplasms, Histopathology, Deep learning, Explainable deep learning, Adenocarcinoma, Deep Learning, Artificial Intelligence, Carcinoma, Non-Small-Cell Lung, Humans, Convolutional neural networks, Lung cancer

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
69
Top 1%
Top 10%
Top 1%
Green
hybrid