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Applied Surface Science Advances
Article . 2025 . Peer-reviewed
License: CC BY
Data sources: Crossref
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ZENODO
Other literature type . 2025
License: CC BY
Data sources: ZENODO
https://doi.org/10.2139/ssrn.5...
Article . 2025 . Peer-reviewed
Data sources: Crossref
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Sol-gel TiO2-based coatings in 3D printed porous Ti-6Al-4V alloy structures as efficient antibacterial drug delivery systems: Thorough structural and biological characterization

Authors: Anna Knaislová; Diana Horkavcová; Eva Jablonská; Dalibor Vojtěch;

Sol-gel TiO2-based coatings in 3D printed porous Ti-6Al-4V alloy structures as efficient antibacterial drug delivery systems: Thorough structural and biological characterization

Abstract

The application of sol-gel coatings on titanium-based materials offers a promising approach for enhancing their bioactivity, antibacterial properties, and adhesion, particularly for biomedical applications. This study focuses, for the first time, on the preparation and characterization of sol-gel TiO2-based coatings containing hydroxyapatite and silver in 3D-printed porous gyroid and dodethick structures. TiO2-based coatings on the standard wrought Ti-Al-V alloy rods were used as a reference. The coatings were applied via the specific dip-coating process developed by the author team. The microstructural analysis revealed that the sol-gel coatings on the reference wrought rod samples were homogeneous and well-adhered. The coatings on the porous gyroid and dodethick structures exhibited some localized cracking due to the complex geometry of the porous structures. Bioactivity was evaluated through the standard in vitro simulated body fluid tests, confirming hydroxyapatite precipitation on HA-containing coatings. Antibacterial properties were assessed against Escherichia coli, demonstrating nearly 100 % bacterial inhibition for Ag-containing coatings. Cytotoxicity tests with L929 fibroblast cells indicated that coatings with lower Ag concentrations in sol were non-toxic, while higher Ag concentrations in sol resulted in reduced cell viability, particularly in gyroid structures.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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