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Chromosomal localization of DBL oncogene sequences

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1989Publisher:Elsevier BVJournal:Genomics, volume 5, pages 546-553 (issn: 0888-7543,

Authors: Tronick, Steven R.; McBride, O. Wesley; Popescu, Nicholas C.; Eva, Alessandra;

doi: 10.1016/0888-7543(89)90022-0

pmid: 2613238

Chromosomal localization of DBL oncogene sequences

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Abstract

The DBL oncogene was generated by rearrangements involving three discontinuous regions of the human genome. Analyses of panels of human X rodent somatic cell hybrids demonstrated that the DBL proto-oncogene located on the X chromosome (just proximal or distal to bands q26-27.2) underwent recombination at its 5' and 3' ends with sequences derived from chromosomes 3 (p13q-ter) and 16 (p13-q22), respectively. DBL was localized to chromosome Xq27-q28 by in situ hybridization. Another oncogene, MCF2, was previously shown to contain sequences derived from Xq27 as well. Comparison of the restriction maps and nucleotide sequences of genomic and cDNA clones representing the chromosome X-specific sequences of the DBL oncogene and MCF2, taken together with their chromosomal localization, indicates that these oncogenes were derived from the same genetic locus.

Related Organizations

National Institute of Health
Pakistan
Laboratory of Molecular and Cellular Biology of Eukaryotes
France
National Cancer Institute
United States

Keywords

Recombination, Genetic, X Chromosome, Base Sequence, Molecular Sequence Data, Restriction Mapping, Chromosome Mapping, Oncogenes, Hybrid Cells, Cosmids, Proto-Oncogene Mas, Chromosome Banding, Blotting, Southern, Mice, Cricetinae, Animals, Humans

6 Research products, page 1 of 1

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