Identification, localization and characterization of the human γ-synuclein gene

descriptionPublicationkeyboard_double_arrow_right Article 29 Jul 1998Publisher:Springer Science and Business Media LLCJournal:Human Genetics, volume 103, pages 106-112 (issn: 0340-6717, eissn: 1432-1203,

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Authors: Lavedan, Christian; Leroy, Elisabeth; Dehejia, Anindya; Buchholtz, Stephanie; Dutra, Amalia; Nussbaum, Robert L.; Polymeropoulos, M. H.;

doi: 10.1007/s004390050792

pmid: 9737786

Identification, localization and characterization of the human γ-synuclein gene

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Abstract

We have identified and characterized a new member of the human synuclein gene family, gamma-synuclein (SNCG). This gene is composed of five exons, which encode a 127 amino acid protein that is highly homologous to alpha-synuclein, which is mutated in some Parkinson's disease families, and to beta-synuclein. The gamma-synuclein gene is localized to chromosome 10q23 and is principally expressed in the brain, particularly in the substantia nigra. We have determined its genomic sequence, and established conditions for sequence analysis of each of the exons. The gamma-synuclein gene, also known as BCSG1, was recently found to be overexpressed in advanced infiltrating carcinoma of the breast. Our survey of the EST database indicated that it might also be overexpressed in an ovarian tumor.

Related Organizations

National Institute of Health
Pakistan
National Human Genome Research Institute
United States
National Institutes of Health
United States

Keywords

Adult, Neurons, Ovarian Neoplasms, Base Sequence, Databases, Factual, Sequence Homology, Amino Acid, Chromosomes, Human, Pair 10, Carcinoma, Ductal, Breast, Molecular Sequence Data, Brain, Chromosome Mapping, Breast Neoplasms, Nerve Tissue Proteins, Exons, Polymerase Chain Reaction, Substantia Nigra, Humans, Female, Amino Acid Sequence, Sequence Alignment

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