The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1994 English Publisher:Springer Science and Business Media LLCJournal:Psychopharmacology, volume 114, pages 672-674 (issn: 0033-3158, eissn: 1432-2072,

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Authors: P, Popik; R T, Layer; P, Skolnick;

doi: 10.1007/bf02245000

pmid: 7531855

The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

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Abstract

Ibogaine is a putative anti-addictive drug with potential efficacy for the treatment of opiate, stimulant, and alcohol abuse. We now report ibogaine is a competitive inhibitor (Ki, 1.01 +/- 0.1 microM) of [3H]MK-801 binding to N-methyl-D-aspartate (NMDA) receptor coupled cation channels. Since MK-801 can attenuate the development of tolerance to morphine and alcohol as well as sensitization to stimulants in preclinical studies, the reported ability of ibogaine to modify drug-seeking behavior in man may be attributable to a blockade of NMDA receptor coupled cation channels.

Related Organizations

National Institutes of Health
United States
National Institute of Health
Pakistan

Keywords

Phencyclidine, In Vitro Techniques, Ligands, Binding, Competitive, Receptors, N-Methyl-D-Aspartate, Ion Channels, Rats, Receptors, Glutamate, Ibogaine, Animals, Dizocilpine Maleate

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