Production of brefeldin-A

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1995 English Publisher:Oxford University Press (OUP)Journal:Journal of Industrial Microbiology, volume 15, pages 5-9 (issn: 0169-4146, eissn: 1476-5535,

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Authors: McCloud, T. G.; Burns, M. P.; Majadly, F. D.; Muschik, G. M.; Miller, D. A.; Poole, K. K.; Roach, J. M.; +2 Authors

doi: 10.1007/bf01570006

pmid: 7662298

Production of brefeldin-A

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Abstract

Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale.

Keywords

Industrial Microbiology, Antibiotics, Antineoplastic, Brefeldin A, Time Factors, Fermentation, Penicillium, Cyclopentanes, Chromatography, High Pressure Liquid

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