Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1990 English Publisher:Springer Science and Business Media LLCJournal:Somatic Cell and Molecular Genetics, volume 16, pages 593-598 (issn: 0740-7750, eissn: 1572-9931,

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Authors: N C, Popescu; S Y, Cheng;

doi: 10.1007/bf01233100

pmid: 2267632

Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2

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Abstract

A cDNA for the gene that encodes a human cytosolic thyroid hormone binding protein (p58) recently has been isolated and sequenced. Analysis of the p58 sequence indicates that it is identical to the subunit of pyruvate kinase, subtype M2. By in situ hybridization, the gene for p58 was mapped to 15q24-25. This localization shows that the p58 gene is not linked to the L-type of pyruvate kinase, which is located on chromosome 1. The p58 gene was found to be activated in several forms of cancer. Current localization will permit us to assess the effect of alterations involving chromosome 15 on the structure and activity of the p58 gene in neoplasms or chromosome syndromes.

Related Organizations

National Institutes of Health
United States
National Institute of Health
Pakistan
National Cancer Institute
United States

Keywords

Chromosomes, Human, Pair 15, Thyroid Hormones, Pyruvate Kinase, Restriction Mapping, Chromosome Mapping, Membrane Proteins, Nucleic Acid Hybridization, Cytosol, Autoradiography, Humans, Cloning, Molecular, Carrier Proteins, Thyroid Hormone-Binding Proteins

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