Construction of Low-Resolution X-Ray Crystallographic Electron Density Maps of the Ribosome

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2001 English Publisher:Elsevier BVJournal:Methods, volume 25, pages 303-308 (issn: 1046-2023,

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Authors: Cate, Jamie H. D.;

doi: 10.1006/meth.2001.1242

pmid: 11860284

Construction of Low-Resolution X-Ray Crystallographic Electron Density Maps of the Ribosome

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Abstract

Advances in X-ray crystallography now allow biological macromolecules of almost any size to be imaged at atomic resolution. Here, I outline the strategy that allowed for the solution of the 70S ribosome structure to 7.8-A resolution. The most important factors involve the effective use of synchrotron radiation and the application of existing crystallographic software to very large structures.

Related Organizations

University of California, Berkeley
United States

Keywords

Models, Molecular, Photons, Normal Distribution, Scattering, Radiation, Electrons, Crystallography, X-Ray, Ribosomes, Algorithms, Software

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