Genomic structure of theEPHA1receptor tyrosinekinase gene

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1999 English Publisher:Elsevier BVJournal:Molecular and Cellular Probes, volume 13, pages 169-173 (issn: 0890-8508,

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Authors: Owshalimpur, D.; Kelley, M. J.;

doi: 10.1006/mcpr.1999.0228

pmid: 10369740

Genomic structure of theEPHA1receptor tyrosinekinase gene

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Abstract

Some receptor tyrosine kinase genes are mutated in inherited and somatically acquired human cancers. To permit mutational analysis, the complete genomic structure of the human EPHA1 gene on chromosome 7q34 was determined and oligonucleotide pairs were designed to amplify coding regions. The gene contains 18 exons, two more than the related tyrosine kinase, EPHB2. Presumed sequencing errors in the published cDNA sequence of EPHA1 were identified in exons 10 and 11. Availability of this information will facilitate mutational analysis of EPHA1.

Related Organizations

National Cancer Institute
United States

Keywords

Base Sequence, Receptor, EphA1, Molecular Sequence Data, Humans, Receptor Protein-Tyrosine Kinases, Exons

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