Localization of the Human CXC Chemokine Subfamily on the Long Arm of Chromosome 4 Using Radiation Hybrids

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1998 English Publisher:Elsevier BVJournal:Genomics, volume 47, pages 136-139 (issn: 0888-7543,

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Authors: Modi, William S.; Chen, Zhang-Qun;

doi: 10.1006/geno.1997.5100

pmid: 9465307

Localization of the Human CXC Chemokine Subfamily on the Long Arm of Chromosome 4 Using Radiation Hybrids

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Abstract

All 12 of the human CXC chemokine genes were physically mapped using gene-specific PCR primers and the GenBridge 4 radiation hybrid panel. Nine genes, PF4, PF4V1, GRO1, GCP2, PPBP, IL8, GRO2, GRO3, and SCYB5, were assigned within a 1.8-cR interval of one another on 4q. Two additional genes, MIG and INP10, map within 0.5 cR of each another and 6 cR distal to the above-mentioned group. The final gene, SDF1, is localized on 10q. Phylogenetic analyses of amino acid sequences revealed that SDF1 is the most divergent member and that the physically separated MIG-INP10 pair constitutes a distinct evolutionary lineage.

Related Organizations

National Cancer Institute
United States
Science Applications International Corporation (United States)
United States

Keywords

Evolution, Molecular, Chromosome Mapping, Humans, Chromosomes, Human, Pair 4, Hybrid Cells, Chemokines, CXC, Polymerase Chain Reaction, Phylogeny

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