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Mapping of the Gene (NRAP) Encoding N-RAP in the Mouse and Human Genomes

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1997Publisher:Elsevier BVJournal:Genomics, volume 45, pages 229-232 (issn: 0888-7543,

Authors: Luo, Gang; Leroy, Elisabeth; Kozak, Christine A.; Polymeropoulos, Mihael H.; Horowits, Robert;

doi: 10.1006/geno.1997.4917

pmid: 9339382

Mapping of the Gene (NRAP) Encoding N-RAP in the Mouse and Human Genomes

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Abstract

N-RAP is a nebulin-related actin-binding protein found at the myotendon junction in skeletal muscle and at the intercalated disks in cardiac muscle. We mapped the NRAP gene to mouse chromosome 19 using interspecific crosses and to human chromosome 10 using radiation hybrid panels. Comparative analysis of the mouse and human genomes indicates that the NRAP gene is located in regions of conserved synteny between the two species.

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Keywords

DNA, Complementary, Base Sequence, Chromosomes, Human, Pair 10, Molecular Sequence Data, Chromosome Mapping, Muscle Proteins, Mice, Sequence Homology, Nucleic Acid, Animals, Humans, Crosses, Genetic

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