Human Synaptotagmin V (SYT5): Sequence, Genomic Structure, and Chromosomal Location

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1997 English Publisher:Elsevier BVJournal:Genomics, volume 42, pages 165-169 (issn: 0888-7543,

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Authors: Craxton, Molly; Olsen, Anne; Goedert, Michel;

doi: 10.1006/geno.1997.4722

pmid: 9177789

Human Synaptotagmin V (SYT5): Sequence, Genomic Structure, and Chromosomal Location

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Abstract

We have determined the sequence, genomic structure, and chromosomal location of the human synaptotagmin V (SYTV) gene. The human SYTV gene encodes a 386-amino-acid product which is 91% identical to rat Syt V. The human SYTV open reading frame is interrupted by seven introns which can be alternatively spliced. Human SYTV was found to lie very close to SYTIII on chromosome 19q13.4 by PCR analysis of somatic cell hybrid DNA and by DNA hybridization to arrayed cosmids of the chromosome 19 metric physical map. This provides the first report of linked synaptotagmin genes.

Related Organizations

Medical Research Council
United Kingdom
Lawrence Berkeley National Laboratory
United States
Lawrence Livermore National Laboratory
United States
MRC Laboratory of Molecular Biology
United Kingdom
Medical Research Council
United Kingdom

Keywords

Membrane Glycoproteins, Base Sequence, Genetic Linkage, Calcium-Binding Proteins, Molecular Sequence Data, Chromosome Mapping, Nerve Tissue Proteins, DNA, Hybrid Cells, Cosmids, Polymerase Chain Reaction, Introns, Rats, Open Reading Frames, Consensus Sequence, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Chromosomes, Human, Pair 19

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