A 500-kb Physical Map and Contig from the Harveyras-1Gene to the 11p Telomere

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1996 English Publisher:Elsevier BVJournal:Genomics, volume 35, pages 353-360 (issn: 0888-7543,

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Authors: Russell, Mark W.; Munroe, David J.; Bric, Eva; Housman, David E.; Dietz-Band, Jeanne; Riethman, Harold C.; Collins, Francis S.; +1 Authors

doi: 10.1006/geno.1996.0367

pmid: 8661149

A 500-kb Physical Map and Contig from the Harveyras-1Gene to the 11p Telomere

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Abstract

A contiguous physical map was constructed from the Harvey ras-1 (HRAS1) gene to the 11p telomere. The contig spans approximately 500 kb and is minimally composed of a telomere-containing YAC and P1 and cosmid clones. Included in the contig are 11 sequence-tagged sites derived from P1 and cosmid ends. Three genes were placed on the contig in the following order: telomere-ribonuclease/angiogenin inhibitor (RNH)-Harvey ras-1 (HRAS1)-HRAS1-related complex (HRC). Two novel tetranucleotide repeats (heterozygosity of 66 and 68%) and a complex CA repeat (heterozygosity of 78%) were isolated and characterized.

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Keywords

Genetic Markers, Polymorphism, Genetic, Base Sequence, Chromosomes, Human, Pair 11, Genetic Carrier Screening, Molecular Sequence Data, Chromosome Mapping, Telomere, Random Amplified Polymorphic DNA Technique, Genes, ras, Humans, Dinucleotide Repeats, Chromosomes, Artificial, Yeast

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