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Chromosomal Organization and Transcriptional Regulation of Human GEM and Localization of the Human and Mouse GEM Loci Encoding an Inducible Ras-Like Protein

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1995Publisher:Elsevier BVJournal:Genomics, volume 30, pages 558-564 (issn: 0888-7543,

Authors: Santoro, Thomas; Maguire, Jean; McBride, O. Wesley; Avraham, Karen B.; Copeland, Neal G.; Jenkins, Nancy A.; Kelly, Kathleen;

doi: 10.1006/geno.1995.1277

pmid: 8825643

Chromosomal Organization and Transcriptional Regulation of Human GEM and Localization of the Human and Mouse GEM Loci Encoding an Inducible Ras-Like Protein

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Abstract

The mitogen-induced gene, GEM, encodes a GTP-binding protein that belongs to a new family within the Ras superfamily. The regulated expression pattern of Gem suggests a role for this protein in cellular responses to growth stimulation. To facilitate the assessment of the possible role of GEM in heritable and spontaneous disease processes, the genomic organization of human GEM and the chromosomal localization of human and murine GEM have been determined. GEM has been localized to the long arm of human chromosome 8 (8q13-q21) between the D8S85 and CA2 loci by genetic linkage analysis using an MspI restriction fragment length polymorphism within GEM. No consistent somatic chromosomal alterations or heritable diseases are associated with this region. Mouse Gem maps to the proximal region of chromosome 4 between Mos and Cga. To gain insight into the transcriptional regulation of GEM, we have established the transcriptional initiation site of GEM in human T cells and defined a 5' upstream region sufficient for mitogen-responsive, inducible transcription.

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Keywords

Base Sequence, Transcription, Genetic, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Retinoblastoma Protein, Chromosomes, Immediate-Early Proteins, Mice, Inbred C57BL, Mice, GTP-Binding Proteins, Sequence Homology, Nucleic Acid, Animals, Humans, Female, DNA Primers, Monomeric GTP-Binding Proteins

14 Research products, page 1 of 2

GTP-binding protein GEM
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Human GEM gene, 5' regulatory region.
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GTP-binding protein
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Mus musculus GEM gene, 5' regulatory region.
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CNTF receptor alpha subunit
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