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Chromosomal Localization of the Human Heme Oxygenase Genes: Heme Oxygenase-1 (HMOX1) Maps to Chromosome 22q12 and Heme Oxygenase-2 (HMOX2) Maps to Chromosome 16p13.3

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1994Publisher:Elsevier BVJournal:Genomics, volume 20, pages 513-516 (issn: 0888-7543,

Authors: Kutty, R. Krishnan; Kutty, Geetha; Rodriguez, Ignacio R.; Chader, Gerald J.; Wiggert, Barbara;

doi: 10.1006/geno.1994.1213

pmid: 8034330

Chromosomal Localization of the Human Heme Oxygenase Genes: Heme Oxygenase-1 (HMOX1) Maps to Chromosome 22q12 and Heme Oxygenase-2 (HMOX2) Maps to Chromosome 16p13.3

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Abstract

Heme oxygenase catalyzes the oxidation of heme to biliverdin, the precursor of the bile pigment bilirubin, and carbon monoxide, a putative neurotransmitter. We have employed polymerase chain reaction and fluorescence in situ hybridization to determine the chromosome localization of the genes coding for the two known heme oxygenase isozymes. Heme oxygenase-1 (HMOX1), the inducible form, was localized to human chromosome 22q12, while heme oxygenase-2 (HMOX2), the constitutive form, was localized to chromosome 16p13.3.

Related Organizations

National Institute of Health
Pakistan
National Institutes of Health
United States
National Eye Institute
United States

Keywords

Base Sequence, Chromosomes, Human, Pair 22, Molecular Sequence Data, Chromosome Mapping, Hominidae, Polymerase Chain Reaction, Isoenzymes, Heme Oxygenase (Decyclizing), Animals, Humans, Chromosomes, Human, Pair 16, In Situ Hybridization, Fluorescence, DNA Primers

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