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Localization of the Gene Encoding the α2/δ Subunit (CACNL2A) of the Human Skeletal Muscle Voltage-Dependent Ca2+ Channel to Chromosome 7q21-q22 by Somatic Cell Hybrid Analysis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994 China (People's Republic of) English Publisher:Elsevier BVJournal:Genomics, volume 19, pages 192-193 (issn: 0888-7543,

Authors: Powers, PA; Scherer, SW; Gregg, RG; Tsui, LC; Hogan, K;

doi: 10.1006/geno.1994.1044

pmid: 8188232

handle: 10722/133889

Localization of the Gene Encoding the α2/δ Subunit (CACNL2A) of the Human Skeletal Muscle Voltage-Dependent Ca2+ Channel to Chromosome 7q21-q22 by Somatic Cell Hybrid Analysis

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Abstract

Activation of voltage-dependent calcium channels (VDCCs) by membrane depolarization triggers key cellular responses such as contraction, secretion, excitation, and electrical signaling. The skeletal muscle L-type VDCC is a heteromultimer complex containing four subunits, [alpha][sub 1],[alpha][sub 2]/[delta],[beta][sub 1], and [gamma]. The [alpha][sub 2]/[delta] subunit, an integral component of the VDCC, appears to modulate the channel kinetics. The [alpha][sub 2]/[delta] gene is expressed in many tissues, including skeletal muscle, brain, heart, and lung, and cDNAs representing the skeletal muscle and brain isoforms have been isolated. DNA sequence comparisons indicate that these cDNAs are encoding by a single gene. 15 refs., 1 fig.

Country

China (People's Republic of)

Related Organizations

University of Toronto
Canada
William S. Middleton Memorial Veterans Hospital
United States
University of Wisconsin Hospital and Clinics
United States
Hospital for Sick Children
Canada
University of Hong Kong (香港大學)
China (People's Republic of)

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Keywords

Base Sequence, Molecular Sequence Data, Chromosome Mapping, Hybrid Cells, Polymerase Chain Reaction, Chromosomes, Yeast, Cricetulus, Genes, Calcium Channels - genetics, Cricetinae, Artificial, Animals, Humans, Pair 7, Calcium Channels, Rabbits, Chromosomes, Artificial, Yeast, Chromosomes, Human, Pair 7, Human

1 Research products, page 1 of 1

Localization of the gene encoding the a_{2}/\delta$-subunits of the L-type voltage-dependent calcium-channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families
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