Cloning and Expression of Human Homolog HSMT3 to Yeast SMT3 Suppressor of MIF2 Mutations in a Centromere Protein Gene

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1996 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 222, pages 178-180 (issn: 0006-291X,

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Authors: Mannen, Hideyuki; Tseng, Hui-Min; Cho, Chung-Lung; Li, Steven S.-L.;

doi: 10.1006/bbrc.1996.0717

pmid: 8630065

Cloning and Expression of Human Homolog HSMT3 to Yeast SMT3 Suppressor of MIF2 Mutations in a Centromere Protein Gene

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Abstract

A human HSMT3 cDNA encoding a homolog of the yeast SMT3, a suppressor of MIF2 mutations in a centromere protein gene, was identified and sequenced. The sequence of 95 amino acids deduced from the human HSMT3 cDNA exhibited 51.1% identity and 69.6% similarity to the yeast Smt3p sequence. The HSMT3 transcripts of 1.35Kb were found to be abundantly expressed in various human tissues.

Related Organizations

National Institutes of Health
United States
National Institute of Health
Pakistan
National Sun Yat-sen University
Taiwan
National Institute of Environmental Health Sciences
United States
Research Triangle Park Foundation
United States

Keywords

DNA, Complementary, Saccharomyces cerevisiae Proteins, Base Sequence, Sequence Homology, Amino Acid, Swine, Centromere, Molecular Sequence Data, Gene Expression, Mitosis, Proteins, Saccharomyces cerevisiae, Fungal Proteins, Repressor Proteins, Small Ubiquitin-Related Modifier Proteins, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Sequence Alignment

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