Structural Organization and Expression of the Human Phosphatidylinositol-Specific Phospholipase C β-3 Gene

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1995 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 212, pages 190-195 (issn: 0006-291X,

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Authors: K, Mazuruk; T J, Schoen; G J, Chader; I R, Rodriguez;

doi: 10.1006/bbrc.1995.1955

pmid: 7612006

Structural Organization and Expression of the Human Phosphatidylinositol-Specific Phospholipase C β-3 Gene

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Abstract

We have cloned and fully sequenced the phospholipase C beta-3 (PLC beta-3) gene. The gene spans approx. 17 kb and consists of 31 exons and 30 introns. All intron-exon junctions obey the GT/AG rule. The gene is highly expressed in several human tissues including retina, brain and kidney; PLC beta-3 mRNA is detected at a much lower level in liver. Because of its importance in signal transduction, its chromosomal localization and its high expression in CNS and other tissues, the PLC beta-3 gene is a candidate in several human genetic diseases which, with the present genomic sequence, can now be fully examined.

Related Organizations

National Institutes of Health
United States
National Eye Institute
United States

Keywords

Base Composition, Base Sequence, Phosphoric Diester Hydrolases, Phosphatidylinositol Diacylglycerol-Lyase, Molecular Sequence Data, Brain, Gene Expression, Hominidae, Exons, Kidney, Polymerase Chain Reaction, Introns, Isoenzymes, Phosphoinositide Phospholipase C, Liver, Organ Specificity, Animals, Humans, Cloning, Molecular, DNA Primers

3 Research products, page 1 of 1

Homo sapiens (human) phospholipase C-beta-3
2018IsRelatedTo
Human phospholipase C-beta-3 (PLCB3) gene, complete cds.
2018IsRelatedTo
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
2017IsRelatedTo

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