descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1993 English Publisher:WileyJournal:Annals of the New York Academy of Sciences, volume 713, pages 338-342 (issn: 0077-8923, eissn: 1749-6632,

Authors: A, de Weerth; J R, Pisegna; K, Huppi; S A, Wank;

doi: 10.1111/j.1749-6632.1994.tb44086.x , 10.1006/bbrc.1993.1894

pmid: 8185181 , 8343165

Molecular Cloning, Functional Expression, and Chromosomal Localization of the Human Cholecystokinin Type A Receptor

- Summary
- Subjects
- Related research
  (4)
- Metrics

Abstract

The results presented here describe for the first time the molecular cloning of the human CCKA-R. Expression of the recombinant receptor shows the expected subtype pharmacology and coupling to phosphoinositide hydrolysis reported for the native human CCKA-R. This knowledge will enhance our understanding of its distribution, pharmacology, and structure and will improve our understanding of its physiological role in the gastrointestinal and nervous systems in humans. Ultimately, this should hasten the understanding and therapy of gastrointestinal and neuropsychiatric disorders.

Related Organizations

National Institutes of Health
United States
National Institute of Diabetes and Digestive and Kidney Diseases
United States
National Institute of Health
Pakistan

Keywords

Placenta, Guinea Pigs, Molecular Sequence Data, Gene Expression, Transfection, Nervous System, Polymerase Chain Reaction, Cell Line, Pregnancy, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Genomic Library, Base Sequence, Sequence Homology, Amino Acid, Chromosome Mapping, Gallbladder, Hominidae, Rats, Kinetics, Oligodeoxyribonucleotides, Organ Specificity, Female, Receptors, Cholecystokinin, Chromosomes, Human, Pair 4, Digestive System

4 Research products, page 1 of 1

Human cholecystokinin A receptor mRNA, complete cds.
2018IsRelatedTo
Cholecystokinin receptor type A
2017IsRelatedTo
Homo sapiens gene for cholecystokinin type-A receptor, complete cds.
2018IsRelatedTo
Homo sapiens (human) cholecystokinin A receptor
2018IsRelatedTo

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	158
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%