ABSTRACT Flat optical metasurfaces are transforming photonics research by enabling new ways to control light in ultrathin, versatile photonic devices. The rise of quasi‐bound states in the continuum (qBIC) metasurfaces has enabled tailored high‐quality (Q) factor resonances in subwavelength nanostructured thin films, analogous to traditional optical cavities. In this perspective, we explore the emergence of cavity quantum electrodynamics (QED) in optical qBIC metasurfaces, specifically those constructed from van der Waals (vdW) layered materials. Because of their remarkable properties, vdW metasurfaces can support intrinsic optical resonances within the same active material hosting luminescent species, such as excitons or defects, leading to optimal light–matter coupling. This approach of self‐hybridizing the cavity‐emitter system into a single platform effectively overcomes limitations in on‐chip integration of conventional cavities. Combining vdW materials with optically engineered qBIC metasurfaces opens exciting possibilities for exploring nanoscale light–matter interactions. Moreover, the distinctive features of vdW materials, from vertical heterostructures to twist‐angle‐dependent properties, offer a unique platform bridging the condensed matter physics of 2D materials and engineered nanophotonics. We propose that harnessing strong light–matter coupling in vdW‐integrated qBIC metasurfaces will pave the way for next‐generation nanoscale polaritonic devices.