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Movement Disorders
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Movement Disorders
Article . 1997 . Peer-reviewed
License: Wiley Online Library User Agreement
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Movement Disorders
Article . 1998
Data sources: Europe PubMed Central
https://dx.doi.org/10.1002/mds...
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https://dx.doi.org/10.1002/mds...
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A gene (ETM) for essential tremor maps to chromosome 2p22‐p25

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1997 English Publisher:WileyJournal:Movement Disorders, volume 12, pages 859-864 (issn: 0885-3185, eissn: 1531-8257, Copyright policy )
Authors: J J, Higgins; L T, Pho; L E, Nee;

doi: 10.1002/mds.870120605

pmid: 9399207

A gene (ETM) for essential tremor maps to chromosome 2p22‐p25

Abstract

AbstractWe report the results of linkage analysis in a large American family of Czech descent with dominantly inherited “Pure” essential tremor (ET) and genetic anticipation. Genetic loci on chromosome 2p22‐p25 establish linkage to this region with a maximum LOD score (Zmax) = 5.92 for the locus, D2S272. Obligate recombinant events place the ETM gene in a 15‐cM candidate interval between the genetic loci D2S168 and D2S224. Repeat expansion detection analysis suggests that expanded CAG trinucleotide sequences are associated with ET. These findings will facilitate the search for an ETM gene and may further our understanding of the human motor system.

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Keywords

Adult, Chromosome Aberrations, X Chromosome, Adolescent, Genetic Linkage, Chromosome Disorders, Middle Aged, Severity of Illness Index, United States, Pedigree, Phenotype, Haplotypes, Trinucleotide Repeats, Chromosomes, Human, Pair 2, Tremor, Humans, Child, Aged, Czech Republic

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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