AbstractBackground and ObjectiveZoon's balanitis (ZB) is an uncommon, benign, idiopathic inflammatory condition affecting uncircumcised males. Definitive treatments include circumcision and carbon dioxide (CO2) laser ablation. We describe an alternative laser modality showing efficacy in the treatment of ZB.Study Design/Materials and MethodsWe report the first case of ZB effectively treated with Erbium:YAG (Er:YAG) laser ablation. We review the pathogenesis and medical, surgical, and laser management of ZB.ResultsOur patient demonstrated a long‐term clinical and histologic cure after Er:YAG laser ablation of ZB.ConclusionsAs an alternative to circumcision or continuous wave CO2 laser, we propose a trial of Er:YAG laser ablation as a low risk, first line treatment of ZB. Lasers Surg. Med. 30:123–126, 2002. © 2002 Wiley‐Liss, Inc.