Isolation of an Intermediate in the Platination of p‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2008 English Publisher:WileyJournal:European Journal of Inorganic Chemistry, volume 2,008, pages 1,183-1,187 (issn: 1434-1948, eissn: 1099-0682,

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Authors: Quiroga, Adoración G.; Cubo, Leticia; Sanz Miguel, Pablo J.; Moneo, Victoria; Carnero, Amancio; Navarro-Ranninger, Carmen;

doi: 10.1002/ejic.200800003

Isolation of an Intermediate in the Platination of p‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

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Abstract

AbstractThe investigation of the formation and reactivity of Pd and Pt thiosemicarbazone complexes has revealed an unstudied intermediate derived from p‐nitroacetophenone 4‐methylthiosemicabazone (L1H2). The L1H2 ligand leads to a new complex [Pt(L1)(L1H2)] that supports the postulated mechanism of how cyclometallation reactions take place. All the newly synthesized complexes, [(Pd(L1)4], [(Pt(L1)4], and [Pt(L1)(L1H2)] (3), have been characterized and tested against MCF7, SF268, and NCI H460 cell lines. The crystal structure of [Pt(L1)(L1H2)]·dmso is reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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