Abstract A case of a 31 years-old woman with complex regional pain syndrome type I (CRPS) of the left arm is described. Brachial plexus block (BPB) has been cited as a treatment modality for CRPS. This report is based on the retrospective observations of the outcome and effects of axillary BPB in a patient with CRPS. 31 Years-old woman suffered from CRPS of the left upper limb after trauma for 5 months. Symptoms over the left upper limb were not alleviated under conventional pharmacological treatment and rehabilitation and severe painful swelling of the left wrist persisted. Axillary BPB with 30 ml Naropaine 0.2% was performed and 12 h later resulted in significant reduction of pain and improvement of function of the left wrist.