Gliomas are highly invasive and aggressive tumors having the highest incidence rate of brain cancer. Identifying effective prognostic and potential therapeutic targets is necessitated. The relationship between pyroptosis and glioma progression is a promising area of research. Understanding the molecular mechanisms underlying pyroptosis in gliomas can provide valuable insights into the development of novel therapeutic strategies. Furthermore, the role of pyroptosis in glioma stem cells and its impact on tumor recurrence and metastasis need to be explored. By elucidating the complex interactions between pyroptosis and glioma progression, researchers can identify potential targets for glioma treatment and improve patient outcomes.