The complement system plays a crucial role in the innate immune response, particularly during inflammation and infection. Neutrophils, a key component of this response, undergo significant changes in morphology and function in response to complement activation. Complement C5a, a potent anaphylatoxin, is a key player in this process, inducing changes in neutrophil morphology that facilitate their migration and function. This research activity aims to investigate the mechanisms underlying C5a-induced changes in neutrophil morphology and their impact on the immune response.