Upon muscle injury, the high mobility group box 1 (HMGB1) protein is upregulated and secreted to initiate reparative responses. This process is crucial for the regeneration of muscle tissue. HMGB1 has been shown to control myogenesis both in vitro and in vivo, highlighting its importance in muscle development and repair. The exact mechanisms by which HMGB1 regulates myogenesis are still not fully understood, but it is believed to interact with various signaling pathways to promote muscle cell differentiation and proliferation. Further research is needed to fully elucidate the role of HMGB1 in myogenesis and to explore its potential as a therapeutic target for muscle-related disorders.